Defining Cell Identity with Single-Cell Omics
نویسندگان
چکیده
منابع مشابه
Defining cell types and states with single-cell genomics.
A revolution in cellular measurement technology is under way: For the first time, we have the ability to monitor global gene regulation in thousands of individual cells in a single experiment. Such experiments will allow us to discover new cell types and states and trace their developmental origins. They overcome fundamental limitations inherent in measurements of bulk cell population that have...
متن کاملSingle-cell genomics: defining microbiology's dark matter.
We all remember this experiment from freshman biology: Take a sterile swab, rub it along the inside of your cheek, and transfer the collected microbes to a sterile agar plate. After incubating the plate overnight at 37 °C, the agar will be awash in bacterial colonies, a glossy and somewhat smelly testament to the fact that humans, fundamentally, are giant microbial buses. Yet that picture, it t...
متن کاملUsing single-cell multiple omics approaches to resolve tumor heterogeneity
It has become increasingly clear that both normal and cancer tissues are composed of heterogeneous populations. Genetic variation can be attributed to the downstream effects of inherited mutations, environmental factors, or inaccurately resolved errors in transcription and replication. When lesions occur in regions that confer a proliferative advantage, it can support clonal expansion, subclona...
متن کاملCellular identity at the single-cell level.
A single cell creates surprising heterogeneity in a multicellular organism. While every organismal cell shares almost an identical genome, molecular interactions in cells alter the use of DNA sequences to modulate the gene of interest for specialization of cellular functions. Each cell gains a unique identity through molecular coding across the DNA, RNA, and protein conversions. On the other ha...
متن کاملDefining cell populations with single-cell gene expression profiling: correlations and identification of astrocyte subpopulations
Single-cell gene expression levels show substantial variations among cells in seemingly homogenous populations. Astrocytes perform many control and regulatory functions in the central nervous system. In contrast to neurons, we have limited knowledge about functional diversity of astrocytes and its molecular basis. To study astrocyte heterogeneity and stem/progenitor cell properties of astrocyte...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PROTEOMICS
سال: 2018
ISSN: 1615-9853
DOI: 10.1002/pmic.201700312